Dr Yaohe Wang
Project Title: Novel therapy for pancreatic cancer using a Lister strain vaccinia virus armed with the therapeutic gene Interleukin-10 Research Aims: The current treatments for pancreatic cancer are relatively ineffective,...
Professor Jason Carroll
...switch the genes on and off. Professor Carroll hopes to use his technique to build a map of the genes and proteins that drive the progression of pancreatic cancer and...
Professor Stephen Neidle
...shrank significantly in size. In a new study funded by PCRF, Prof. Neidle and his team aim to optimise this potential drug to be as active and efficient as possible...
Professor Marco Falasca
...role of a specific PI3K isoform p110 gamma in pancreatic cancer. Our hypothesis is that p110gamma overexpression is a frequent and early event in pancreatic cancer progression and could therefore...
Dr Claire Wells
...family GTPases; Rho, Rac, and Cdc42. There is considerable evidence that Rac/Cdc42interacting proteins, the p-21 activated kinase family (PAK1-6), may play a key role in cell migration and regulation of...
Professor Caroline Dive
Project Title: Development of blood-borne biomarkers for improving treatment selection for pancreatic cancer patients Project Aims: Professor Dive and her team will analyse stray tumour cells that circulate in the...
Dr Fieke Froeling
Project Title: Novel strategies for pancreatic cancer treatment: an epigenetic approach Project Aims: Dr Froeling‘s project will focus on ‘epigenetics’ – changes in DNA that can switch genes on and...
Professor Hemant Kocher
...the medium to long term (5-10 years) to abrogate the abnormal FGF signalling. Thus if we can modify these local hormones to affect cancer growth and allow anti-cancer agents to...
Professor Michael Schmid
...are naturally primed to detect and kill cancer cells, but when a tumour starts to form in the liver, this ability is suppressed, allowing cancer cells to grow and form...
Dr Tanja Crnogorac-Jurcevic
...further validate urinary biomarkers (potentially incorporating further molecules called miRNAs) and develop a combined ‘risk score’ for each biomarker in a panel – a step which is crucial for interpreting...